GLP-Based Peptides

Glucagon-like peptide-1 (GLP-1) and related analogues have emerged as significant modulators of metabolic and reproductive function.

Metabolic Signalling

GLP-1 receptor agonists influence glucose homeostasis, insulin sensitivity and appetite regulation. These metabolic effects have downstream implications for reproductive endocrinology, particularly in conditions like PCOS where insulin resistance plays a central role.

Inflammation & Reproduction

Emerging research suggests GLP-1 signalling may modulate inflammatory pathways relevant to ovarian function and endometrial receptivity. Anti-inflammatory effects could support follicular development and implantation biology.

Clinical Considerations

• Weight management in metabolic infertility

• PCOS-related ovulatory dysfunction

• Insulin resistance and reproductive outcomes

• Timing considerations around conception

Research note: GLP-1 agonists are approved for metabolic indications. Use in fertility contexts requires careful consideration of timing, contraindications and regulatory status.