SS-31 & Mitochondria

SS-31 (Elamipretide) is a mitochondria-targeted peptide with emerging relevance to oocyte and sperm energetics.

Mitochondrial Targeting

SS-31 selectively concentrates in the inner mitochondrial membrane, where it interacts with cardiolipin. This stabilises membrane potential, optimises electron transport chain efficiency and reduces reactive oxygen species production.

Oocyte Energetics

Oocytes are among the most mitochondria-dense cells in the body. Mitochondrial dysfunction is increasingly recognised as a driver of age-related oocyte quality decline. SS-31 research explores whether supporting mitochondrial function can influence reproductive outcomes.

Sperm Bioenergetics

Sperm motility depends on mitochondrial ATP production. Oxidative stress damages sperm DNA and membrane integrity. Mitochondria-targeted antioxidants like SS-31 are being investigated for male factor infertility.

Research Focus

• Age-related mitochondrial dysfunction in oocytes

• Oxidative stress and gamete quality

• ATP production and cellular resilience

• Mitochondrial transfer and regenerative approaches

Research note: SS-31 is in clinical trials for mitochondrial myopathies and heart failure. Fertility applications remain preclinical and investigational.