Kisspeptin Pathways
Kisspeptin is a master regulator of the hypothalamic-pituitary-gonadal axis, essential for puberty initiation and reproductive function.
Reproductive Axis Control
Kisspeptin neurons in the hypothalamus directly stimulate GnRH release, which triggers the cascade of LH and FSH secretion. This positions kisspeptin as a fundamental regulator of ovulation and spermatogenesis.
Ovulation Biology
Kisspeptin administration can trigger ovulation in women, offering a potentially more physiological alternative to hCG in IVF protocols. Research suggests reduced risk of ovarian hyperstimulation syndrome compared to conventional triggers.
Endocrine Synchrony
Kisspeptin integrates metabolic signals, stress responses and circadian rhythms with reproductive function. Understanding this integration may explain some cases of functional hypothalamic amenorrhoea and stress-related infertility.
Clinical Applications
IVF trigger protocols and OHSS risk reduction
Hypothalamic amenorrhoea evaluation
Diagnostic testing of HPG axis integrity
Male hypogonadotropic hypogonadism
Research note: Kisspeptin is actively studied in reproductive medicine with clinical trials ongoing. It represents one of the most promising peptide targets in fertility science.